What to do about Cushing's?
Cushing's syndrome in horses, also known as Equine Cushing's Syndrome (ECS), is a common metabolic disease that primarily affects older horses. If you own a horse, you should be aware of the symptoms such as excessive sweating, long hair, and muscle wasting. This disease is incurable, but can be alleviated through targeted therapy and feeding. In this article, you will learn everything you need to know about the causes, symptoms, and treatment options to enable your animal to live a better life.

What is Cushing's syndrome in horses?
Definition and Overview
Cushing's syndrome, also known as Equine Cushing's Syndrome (ECS), is a common metabolic disease in horses that primarily affects older animals. This condition is characterized by excessive production of certain hormones in the pituitary gland, leading to a variety of symptoms, including long hair, muscle wasting, and laminitis.
The Role of the Pituitary Gland
The pituitary gland plays a central role in your horse's hormone system. In Cushing's syndrome in horses, the regulation of this gland is disrupted, leading to excessive hormone production.
In detail, this means that certain cells in the pituitary gland, which are normally responsible for hormone regulation, release reduced dopamine. This causes the gland to produce unhealthy levels of hormones such as pro-opiomelanocortin (POMC). POMC is then converted into other hormones, including ACTH, which is crucial for the development of symptoms in ECS. This hormonal imbalance has far-reaching consequences that can significantly impair your horse's quality of life.
Causes of Cushing's Syndrome
Hormonal Imbalance
Cushing's syndrome in horses is the result of a hormonal dysregulation that originates in the pituitary gland. Here, certain cells produce an excessive amount of hormones, leading to the typical symptoms of this metabolic disease. Such a disorder can significantly impair your horse's life and requires special attention.
The Influence of Dopamine on POMC Production
Dopamine plays a crucial role in regulating hormone release in the pituitary gland. In horses with Cushing's syndrome, less dopamine is released, leading to excessive production of pro-opiomelanocortin (POMC). This disruption leads to a chain reaction that causes harmful hormonal changes.
The lack of dopamine causes the activity of dopamine-producing cells in the brain to decrease. As a result, too much POMC is produced, from which various messenger substances such as ACTH are formed. These hormones contribute to the development of Cushing's syndrome symptoms and can negatively affect your horse's well-being. Understanding these physiological processes is crucial for recognizing and adequately treating the disease.

Symptoms of Cushing's Syndrome
Physical Characteristics
Horses with Cushing's syndrome often show striking physical characteristics. These include longer and thicker hair, which is often wavy or curly, as well as a disturbed coat change. In addition, the animal may lose weight and decline in health, which manifests as muscle wasting.
Behavioral Changes
Your horse's behavior can also be affected by Cushing's. It becomes less active, sweats easily, and sometimes shows development of apathy. This not only changes the activity level but also the bond with you and the general well-being.
These behavioral changes are often subtle but can intensify as the disease progresses. You might notice your horse having less enjoyment in training or activities it used to love. Reduced energy and quick fatigue can lead to a frustrating situation for both you and your horse.
Common Health Problems
Horses with Cushing's are more susceptible to various health problems. These include laminitis, which is caused by insulin resistance, as well as an increased susceptibility to infections and impaired wound healing.
These common health problems are particularly concerning as they can significantly impair your horse's quality of life. It is important to be attentive if your horse shows signs such as hoof abscesses or slow wound healing. Early detection and treatment of these symptoms are crucial to promote your horse's well-being and prevent serious complications.
Diagnosis and Treatment
Identifying Cushing's Syndrome
The diagnosis of Cushing's syndrome in horses requires careful observation of symptoms. You should look for signs such as unusually long hair, muscle wasting, and altered activity in your horse. A blood test can help determine hormone levels and make an early diagnosis.
Treatment Options for Affected Horses
The treatment of Cushing's in horses is usually long-term and includes medication therapies prescribed by the veterinarian. An interdisciplinary approach that considers diet and lifestyle is also important.
Among the most common treatment options are medication therapies such as pergolide, which regulates hormone balance. You can also adjust your horse's diet to reduce insulin resistance and prevent obesity. Regular veterinary check-ups are essential to monitor progress and make adjustments to therapy. Hoof care is also crucial to prevent laminitis. It is very important to observe your horse well and react to changes so that you can offer it a more livable life.
Prevention and Management
Nutrition and Feeding Strategies
A balanced diet is crucial for the well-being of your horse with Cushing's. Make sure the feeding is low in sugar and starch so as not to additionally burden the sugar metabolism. High-quality hay and avoiding sugary feeds can help stabilize your horse's health. The addition of special supplementary feeds can also be useful to optimize nutrient supply.
Supplementary Feed for Cushing Horses
Unilateral nutrition, high performance demands, and environmental pollution often lead to deficiency symptoms and metabolic problems in horses, especially with Cushing's. The metabolic booster for horses developed by Sandra Fencl in collaboration with the Katharinen Pharmacy in Unterhaching is the ideal solution.
This supplementary feed provides your horse with important vitamins, minerals, and trace elements that are often lacking in the daily diet. Numerous customers report increased vitality and improved performance in their horses. The metabolic booster stabilizes metabolism and noticeably improves the well-being of horses with Cushing's syndrome.
Reducing the Risk of Cushing's Syndrome
To reduce the risk of developing Cushing's, it is important to perform regular veterinary examinations. Look for early symptoms such as altered coat or muscle wasting, and do not hesitate to contact a specialist if you suspect changes. You should also ensure regular exercise and a stress-free environment for your horse to promote well-being.
Additionally, you can support your horse's health by ensuring appropriate vaccination and deworming. A healthy lifestyle, including regular hoof care and avoiding obesity, can also reduce the likelihood of the disease. Inform yourself about your horse's specific needs and adjust care and maintenance accordingly to avoid long-term health problems.

Affected Horses and Breeds
Age and Breed Sensitivity
You should know that Cushing's syndrome primarily affects older horses. Approximately 22 percent of horses and ponies aged about 15 years and older suffer from this metabolic disease, with the proportion increasing with age. Horses aged 16 to 20 years are particularly affected, with up to 64 percent showing signs.
Prevalence of Cushing's Syndrome
Cushing's in horses is widespread. It is estimated that up to 95 percent of horses aged 30 years are affected. This high prevalence shows that older horses should receive special attention and regular veterinary check-ups.
The prevalence of Cushing's syndrome in older horses is alarming. Many symptoms could go unnoticed, meaning the disease is often only recognized late. In more than 13 percent of affected animals, serious symptoms such as chronic laminitis also occur, which can significantly impair quality of life. Therefore, it is important to regularly look for symptoms of this metabolic disease to be able to help your horse early.
Consequences of Cushing's Syndrome
Long-Term Health Effects
Cushing's syndrome in horses leads to significant long-term problems, such as increased susceptibility to infections, parasites, and muscle wasting. In affected horses, wounds heal slower, which increases the risk of diseases. In advanced stages, the quality of life significantly decreases, and serious concomitant diseases such as kidney dysfunction often occur.
Impact on Quality of Life
The ECS significantly impairs your horse's quality of life, as the symptoms affect overall well-being. As the disease progresses, your horse may suffer from apathy and be less active, which diminishes its joy of life.
The symptoms of Cushing's syndrome, such as long, thick hair and insulin resistance, can noticeably burden your horse. In addition, laminitis and other unpleasant ailments are common, severely restricting normal movement. Your ability to keep your horse active and happy is significantly impaired by physical limitations and gradual changes. Therefore, it is important to act early and take appropriate measures to improve your horse's quality of life. Create an environment that allows your animal to live as healthy a life as possible.
Conclusion
Equine Cushing's Syndrome is a common metabolic disease that particularly affects older horses. You should keep an eye on symptoms such as excessive sweating, long hair, and muscle wasting. Early diagnosis and appropriate therapies, such as medication, can significantly improve your horse's quality of life. Also, pay attention to an adapted diet and regular veterinary check-ups to promote your horse's well-being and avoid complications.
These questions about Cushing's in horses are frequently asked:
1. How long can a horse with Cushing's live?
With proper care and treatment, a horse with Cushing's syndrome can live for many years. Life expectancy depends on the severity of the disease and the response to treatment. Many horses lead a relatively normal life if the disease is diagnosed early and well managed.
2. What should a Cushing's horse not eat?
A Cushing's horse should not be given sugary and starchy feeds, as these can raise blood sugar levels. This includes grains, sweet treats, and fresh grass in large quantities. A diet rich in high-fiber feeds and low in sugar is ideal.
3. How does Cushing's manifest in horses?
Cushing's often manifests with symptoms such as long, curly hair that does not shed in spring, weight loss, increased drinking and urination, muscle wastage, and recurrent laminitis. Other signs may include lethargy and increased susceptibility to infection. An accurate diagnosis requires a blood test by a veterinarian.
4. Can a horse with Cushing's be ridden?
Yes, a horse with Cushing's can often still be ridden if it is otherwise healthy and pain-free. However, the intensity and duration of riding should be adjusted to the horse's condition. Regular veterinary examinations are important to ensure the horse is fit enough for physical activity.
5. Does a Cushing's horse experience pain?
Cushing's syndrome itself usually does not cause pain. However, co-occurring conditions like laminitis can be painful. It's important to regularly check the horse for pain and take appropriate measures to ensure its well-being.
6. How much does it cost to treat a horse with Cushing's syndrome?
The cost of treating a horse with Cushing's syndrome can vary. It includes regular veterinary examinations, blood tests, and medications such as pergolide. The monthly cost for medication alone can range from 50 to 150 Euros, depending on the dosage and the specific needs of the horse.
7. Should a horse with Cushing's syndrome be in the pasture?
A horse with Cushing's syndrome can be in the pasture, but grazing should be monitored and possibly restricted to control the consumption of fresh grass. Caution should be exercised especially in spring and autumn, when grass has a high sugar content. Adjusted grazing times and possibly a muzzle can be helpful to reduce sugar intake.
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